In Silico Analysis of Gene Expression Location and Single Nucleotide Polymorphisms (SNPs) of The Glucagon Like Peptide 1 Receptor (GLP-1R)

Association studies of SNPs have become very important in determining how genetic variants are linked to complex diseases, quantitative traits, and physiological responses. Genetic polymorphisms the GLP-1R gene potentially decreased protein stability associated with many especially diabetes obesity. This study aimed screen expression investigate polymorphism by using several beneficial bioinformatics tools. We observed database Ensembl, GTEx portal, KEGG identify structure, expression, molecular pathway GLP-1R. In silico computational methods (SIFT, PolyPhen v2, PROVEAN, PhD-SNP) were used nsSNPs that influence structure function. I-Mutant was possibly damaging nsSNPs, while GeneMANIA gene-gene interactions. is localized on chromosome 6p21, contains 13 exons, has regulation variant (CTCF, promotor, enhancer, promotor flank region). highly expressed pancreas stimulate glucose-dependent insulin secretion suppress glucagon secretion. Seven found be deleterious: rs10305421, rs201672448, rs10305492, rs2295006, rs6923761, rs1042044, rs140642887, rs10305510. server showed rs140642887 unstable, stability, impaired other genes' interaction function (SP1, SP3, GNAS, GCG). first analysis polymorphic gene, will serve as a great resource for developing precision medications treat diseases these polymorphisms.